Brain Tumor Clinical Trials and Research | Norton Healthcare Louisville, Ky.

Brain Tumor Clinical Trials and Research

Norton Brain Tumor Center is at the forefront of central nervous system tumor treatment research. As principal investigators on numerous trials, our specialist physicians have unparalleled experience with many innovative treatments once they are approved for broad use. Patients also may be eligible to take part in these experimental brain tumor treatments. Norton Brain Tumor Center researchers also contribute to groundbreaking studies and other publications in peer-reviewed journals.

Learn more about participating in a clinical trial at Norton Healthcare.

Brain Tumor Clinical Trials and Studies

COVID-19 Infection

COViMS (COVID-19 Infections in MS & Related Diseases) is a joint effort of the US National MS Society and the Consortium of MS Centers to capture information on outcomes of people with MS and other CNS demyelinating diseases (Neuromyelitis Optica Spectrum Disease, or MOG antibody disease) who have developed COVID-19
Study Type: Registry
Geeta Ganesh  M.D.
Geeta Ganesh M.D.
Principal Investigator
Norton Neuroscience Institute
Sponsor: US National MS Society / Consortium of MS Centers

Glioblastoma

EF-32 (TRIDENT): A Pivotal Randomized, Open-Label Study of Optune® (TTFields, 200khz) Concomitant with Radiation Therapy and Temozolomide for the Treatment of Newly Diagnosed Glioblastoma
Study Type: Device Study
Renato LaRocca  M.D.
Renato LaRocca M.D.
Principal Investigator
Norton Brain Tumor Center
Sponsor: NovoCure

Glioblastoma

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1
Study Type: Drug Study
Kaylyn Sinicrope, M.D.
Kaylyn Sinicrope, M.D.
Principal Investigator
Norton Brain Tumor Center
Sponsor: Denovo Biopharma LLC

Glioma

NCCTG N0577/Endorsed Study: Phase III Intergroup Study of Radiotherapy versus Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma
Study Type: Drug Study
Aaron Spalding  M.D.
Aaron Spalding M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Radiation Therapy Oncology Group (RTOG)

Newly Diagnosed Glioblastoma

Prospective Randomized Placebo-Controlled Trial of SurVaxM Plus Adjuvant Temozolomide for Newly Diagnosed Glioblastoma (SURVIVE)
Study Type: Drug Study
Renato LaRocca  M.D.
Renato LaRocca M.D.
Principal Investigator
Norton Brain Tumor Center
Sponsor: MimiVax, LLC

Primary Central Nervous System Lymphoma

An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)
Study Type: Drug Study
Don Stevens  M.D.
Don Stevens M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: ONO Pharmaceutical Co., Ltd.

Recurrent Glioblastoma

A Phase II Open-label Study Investigating the Efficacy, Safety and Pharmacokinetic Properties of OKN-007 Combined with Temozolomide in Patients with Recurrent Glioblastoma
Study Type: Drug Study
Kaylyn Sinicrope, M.D.
Kaylyn Sinicrope, M.D.
Principal Investigator
Norton Brain Tumor Center
Sponsor: Oblato, Inc.

Registry

AANS and ASTRO Stereotactic Radiosurgery Registry (SRS Registry)
Study Type: Registry
Aaron Spalding  M.D.
Aaron Spalding M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: NeuroPoint Alliance

Registry

Laser Ablation of Abnormal Neurological Tissue using Robotic Neuroblate system (LAANTERN) Prospective Registry
Study Type: Registry
David Sun  M.D.
David Sun M.D.
Principal Investigator
Norton Brain Tumor Center
Sponsor: Monteris Medical Corporation
Clinical trials

Clinical Trials

Learn more about clinical trials at Norton Healthcare
(502) 629-3500

COVID-19 was a blessing for this woman — it helped reveal a brain tumor

Linda Bowden came down with COVID-19 last summer. Little did she know, the diagnosis may have saved her life. After about a month of treatment for blood clots in her right lung, Linda, 53, passed […]

Read Full Story

Eight-time century rider remembers his brother in Bike to Beat Cancer

Completing one century ride in life is a goal for many. Bike to Beat Cancer rider Scott Walters has achieved that goal eight times, riding the 100-mile route in Bike to Beat Cancer for the […]

Read Full Story

Six years after his brain cancer diagnosis, a glioblastoma survivor and his wife look to the future

John and Jessica Bostock were in the middle of exciting life changes as the summer of 2015 started warming up. John was just 35, and the couple had an 18-month-old daughter, Olive. Plans were underway […]

Read Full Story

The latest in noninvasive brain tumor treatment

TrueBeam, CyberKnife and Gamma Knife may sound like superheroes, but actually they are tools for treating brain tumors. These three machines are used for stereotactic radiosurgery (SRS), a non-surgical treatment option that uses high doses […]

Read Full Story

Brain cancer doesn’t stop for the pandemic; it didn’t stop for Ben Smith

A seizure in late May, followed by another in early June led Ben Smith to the emergency department at Norton Women’s & Children’s Hospital. Visitor restrictions were in place due to the coronavirus pandemic, but […]

Read Full Story
Related Stories

COVID-19 was a blessing for this woman — it helped reveal a brain tumor

Linda Bowden came down with COVID-19 last summer. Little did she know, the diagnosis may have saved her life. After about a month of treatment for blood clots in her right lung, Linda, 53, passed […]

Read Full Story

Eight-time century rider remembers his brother in Bike to Beat Cancer

Completing one century ride in life is a goal for many. Bike to Beat Cancer rider Scott Walters has achieved that goal eight times, riding the 100-mile route in Bike to Beat Cancer for the […]

Read Full Story

Six years after his brain cancer diagnosis, a glioblastoma survivor and his wife look to the future

John and Jessica Bostock were in the middle of exciting life changes as the summer of 2015 started warming up. John was just 35, and the couple had an 18-month-old daughter, Olive. Plans were underway […]

Read Full Story

The latest in noninvasive brain tumor treatment

TrueBeam, CyberKnife and Gamma Knife may sound like superheroes, but actually they are tools for treating brain tumors. These three machines are used for stereotactic radiosurgery (SRS), a non-surgical treatment option that uses high doses […]

Read Full Story

Brain cancer doesn’t stop for the pandemic; it didn’t stop for Ben Smith

A seizure in late May, followed by another in early June led Ben Smith to the emergency department at Norton Women’s & Children’s Hospital. Visitor restrictions were in place due to the coronavirus pandemic, but […]

Read Full Story

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