Norton Heart & Vascular Institute Clinical Trials

Norton Heart and Vascular Institute physicians are innovators in patient care. As principal investigators on numerous trials, our specialist physicians have access to ground-breaking treatments.

Learn more about participating in a clinical trial at Norton Healthcare.

Active clinical trials at Norton Heart & Vascular Institute include:

Acute Coronary Syndrome (ACS)

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome

Acute Decompensated Heart Failure (ADHF)

A multicenter, randomized, double-blind, double-dummy, parallel group, active controlled 8-week study to evaluate the effect of sacubitril/valsartan (LCZ696) versus valsartan on changes in NT-proBNP and safety and tolerability of in-hospital initiation of LCZ696 compared to […]

Chronic Heart Failure

A phase III randomised, double-blind trial to evaluate efficacy and safety of once daily empagliflozin 10 mg compared to placebo, in patients with chronic Heart Failure with preserved Ejection Fraction (HFpEF)

Graft Procedure

Jostent GraftMaster Coronary Stent Graft & Delivery System for the treatement of free perforation, defined as free contrast extravasation into the pericardium, in native coronary vessels or saphenous vein bypass grafts

Heart Failure

Product Surveillance Registry / Site 10123001

Heart Failure

Care Optimization through Patient and Hospital Engagement Clinical Trial for Heart Failure, CONNECT-HF trial

Lung Surgery

HUMANITARIAN USE DEVICE: The Spiration® Valve System Protocol# H060002

Clinical trials

Clinical Trials

Learn more about clinical trials at Norton Healthcare
(502) 629-3501

TAVR vs. open heart surgery: What are the differences?

The minimally invasive transcatheter aortic valve replacement (TAVR) procedure — once thought appropriate only for the sickest aortic stenosis patients — increasingly is being used as an alternative to open heart surgery valve replacement. TAVR […]

Read Full Story

New study supports move toward medication for heart blockages without symptoms

A new study supporting medications for patients with severe but stable heart disease is in line with other evidence suggesting many can hold off on minimally invasive procedures or open-heart surgery, according to a Louisville […]

Read Full Story

Consider these heart-healthy recipe substitutions when cooking or baking

Many recipes can be made more heart-healthy, simply by swapping some high-fat, high-salt ingredients for healthier ones. Here are some easy swaps: Replace This With This Regular or reduced-fat peanut butter Natural peanut butter   […]

Read Full Story

Louisville native brings prestigious medical training back home to treat heart patients

For Mostafa El-Refai, M.D., interventional cardiology is the best of both worlds. He gets to perform lifesaving procedures — inserting stents to open blocked arteries after heart attacks. As an interventional cardiologist with Norton Heart [...]

Read Full Story

Kentucky has country’s highest rate of lung cancer diagnoses; lung cancer screenings urged

Nearly one in every thousand Kentuckians will be newly diagnosed with lung cancer this year — the worst rate in the nation — and most of those cases will be found after the cancer has […]

Read Full Story
Related Stories

TAVR vs. open heart surgery: What are the differences?

The minimally invasive transcatheter aortic valve replacement (TAVR) procedure — once thought appropriate only for the sickest aortic stenosis patients — increasingly is being used as an alternative to open heart surgery valve replacement. TAVR […]

Read Full Story

New study supports move toward medication for heart blockages without symptoms

A new study supporting medications for patients with severe but stable heart disease is in line with other evidence suggesting many can hold off on minimally invasive procedures or open-heart surgery, according to a Louisville […]

Read Full Story

Consider these heart-healthy recipe substitutions when cooking or baking

Many recipes can be made more heart-healthy, simply by swapping some high-fat, high-salt ingredients for healthier ones. Here are some easy swaps: Replace This With This Regular or reduced-fat peanut butter Natural peanut butter   […]

Read Full Story

Louisville native brings prestigious medical training back home to treat heart patients

For Mostafa El-Refai, M.D., interventional cardiology is the best of both worlds. He gets to perform lifesaving procedures — inserting stents to open blocked arteries after heart attacks. As an interventional cardiologist with Norton Heart [...]

Read Full Story

Kentucky has country’s highest rate of lung cancer diagnoses; lung cancer screenings urged

Nearly one in every thousand Kentuckians will be newly diagnosed with lung cancer this year — the worst rate in the nation — and most of those cases will be found after the cancer has […]

Read Full Story

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