Esophageal Cancer Care

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Esophageal Cancer Expertise With a Multidisciplinary Care Team

Esophageal cancer can be complex. At Norton Cancer Institute, you’ll see a multidisciplinary team of surgical oncologists, medical and radiation oncologists, interventional radiologists, gastroenterologists, pathologists, nurse navigators, registered dietitians and more to evaluate and guide your treatment. All bring their own areas of expertise to your case at weekly meetings to review and plan your treatment. Our multidisciplinary team works together at the same location, allowing you to schedule multiple appointments for the same day. 

To contact our gastrointestinal cancer care team, call (502) 629-2500 or email [email protected].

Your care will be coordinated by our gastrointestinal cancer patient navigator who will guide you through treatment. Our navigator is a registered nurse and advocate for patients and families and can help coordinate scheduling and provide information and support throughout your diagnosis, treatment and beyond.

In addition to our current leading-edge treatments, we offer our patients the opportunity to participate in innovative National Cancer Institute and industry-sponsored clinical trials and studies.

What Is Esophageal Cancer?

Esophageal cancer describes the formation of malignant cancer cells in the muscular tube that moves food from your throat to your stomach. There are two forms of esophageal cancer. The most common is esophageal adenocarcinoma, which forms in the glandular cells in the esophageal lining.  Esophageal adenocarcinoma typically affects the lower esophagus, in the area where the esophagus meets the stomach. This form of esophageal cancer is strongly associated with gastrointestinal reflux disease (GERD) or Barrett’s esophagus, two conditions where abnormal cells develop in the esophageal lining due to chronic acid exposure.  

Esophageal squamous cell carcinoma is less common and forms in the flat cells that line the esophagus. This form of esophageal cancer tends to develop in the middle to upper sections of the esophagus. 

Esophageal Cancer Symptoms

The most common first symptom of esophageal cancer is the feeling that food is lodged in the throat or chest. This will get worse as time goes on. Other signs of esophageal cancer include chest pain or discomfort that feels like acid reflux pain, or burning or a pressure feeling in the middle of the chest, especially after swallowing.

No two cancers are alike — you may have no symptoms, your symptoms may be a sign of something other than esophageal cancer, or you may have a unique combination of symptoms.

Although doctors aren’t sure exactly what causes esophageal cancer, many known risk factors can increase the likelihood of developing this type of cancer, including:

  • Smoking
  • Heavy alcohol consumption
  • Chronic heartburn or acid reflux
  • Gastroesophageal reflux disease (GERD)
  • Barrett’s esophagus
  • Obesity
  • Diets high in processed foods and low in fruits and vegetables Physical inactivity
  • Genetic mutations

Diagnosing Esophageal Cancer

The first thing your doctor will do if you have esophageal cancer symptoms is take a detailed medical history, including any risk factors or symptoms you may have. From there, your health care provider will determine the appropriate next step. Those steps might include:

  • Endoscopy with biopsy, a procedure in which a flexible, narrow tube with a tiny video camera and light on the end is used to look inside the body. Tests that use endoscopes can help diagnose esophageal cancer or determine the extent of its spread.
  • Imaging studies, including a CT scan, positron emission tomography (PET) scan or endoscopic ultrasound can help diagnose the cancer and determine its stage.
  • Blood tests, including a complete blood count (CBC), will be done to check for anemia from chronic bleeding. Liver function blood tests may be ordered to help your doctor evaluate your liver function or see if the cancer has spread.
  • Swallow tests, which can be done alone or with other tests, involve drinking a thick, chalky liquid called barium to coat the walls of the esophagus. When X-rays are taken, the barium outlines the esophagus.

Esophageal Cancer Staging

Proper cancer staging helps your team determine the most effective treatment options for you. Stages of esophageal cancer may be grouped into three main categories based on the cancer size and whether or not it has spread to other areas of the body.

  • Early-stage cancer has not grown beyond the inner lining of the esophagus, is small (less than 2 centimeters in diameter) and does not involve any lymph nodes.
  • Locoregional or locally advanced cancer invades the esophagus wall and/or involves nearby lymph nodes.
  • Metastatic cancer has spread to other parts of the body away from the esophagus. The most common sites include the liver, lungs, distant lymph nodes, bone and brain.

Esophageal cancer also may be staged using the tumor, node, metastasis (TNM) system. The letters T, N and M describe different areas of cancer growth. A number is assigned to each letter, based on imaging and pathology results. A TNM example may look like: T2N1M0 or T2, N1, M0.

  • T (tumor) – depth and spread of the main (primary) tumor in the wall of the esophagus
  • N (node) – if cancer has spread to nearby lymph nodes
  • M (metastasis) – if cancer has spread to other parts of the body away from the esophagus

Esophageal Cancer Treatment Options

There are many options for treating esophageal cancer, depending on the cancer stage, whether the cancer has spread and your overall health. Treatment options include:

  • Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) use an endoscope passed down the esophagus to visualize the tumor then remove it through suction or cutting away (early-stage cancers).
  • Endoscopic ablation uses extreme cold or heat, microwaves or chemicals to destroy cancer cells (early-stage cancers).
  • Chemoradiation therapy combines radiation and chemotherapies.
  • Esophageal cancer surgery treats the cancer by removing small tumors, part of the esophagus (esophagectomy) or part of the esophagus plus the upper part of the stomach and affected lymph nodes (esophagogastrectomy). Surgery is typically used to treat early-stage or locally advanced cancer.
  • Radiation therapy uses high-energy X-ray beams to precisely target the cancer.
  • Chemotherapy uses powerful drugs to kill cancer cells.
  • Immunotherapy helps your body’s natural immune system fight cancer and may be recommended following surgery.
  • A clinical trial may offer access to the latest research and an innovative treatment option for your specific type of cancer.

Our multidisciplinary team provides care to over 750 gastrointestinal cancer patients each year, making Norton Cancer Institute the largest comprehensive gastrointestinal cancer program in the region.   

Gastrointestinal Cancer Team

Norton Cancer Institute

Regional Leader in Cancer Care

  • First in the world to treat a patient with a novel combination therapy for newly diagnosed acute leukemia
  • First in the world to treat a solid tumor patient with ONC-841, a novel immunotherapy drug targeting the SIGLEC-10 immune checkpoint molecule
  • Recognized for adult oncology by Becker’s Hospital Review in its “100 Hospitals and Health Systems with Great Oncology Programs” list for 2025
  • Access to over 170 clinical trials, offering local patients the same leading-edge options available at top national centers
  • Nationally recognized center for early-phase research, with 23 active Phase 1 clinical trials underway
  • Patients from 20-plus U.S. states and two foreign countries have chosen Norton Cancer Institute for innovative cancer care
  • Only in Kentucky: Home to a state-of-the-art Norton Cancer Institute Genomics Lab, with support from the Norton Healthcare Foundation and Steven Vanover Foundation, enabling highly precise, genetically targeted cancer therapies
  • Gamma Tile Center of Excellence, as well as a two-time Novalis certification for setting the standard for stereotactic radiation
  • Subspecialized, board-certified oncologists leading cancer research and treatment advancements
  • Same-day or next-day appointments for newly diagnosed patients, plus multiple locations and valet parking to facilitate access to care
  • Multidisciplinary clinics to provide same-day, same-location access to multiple specialists for more convenient, coordinated care
  • Fully accredited by the American College of Surgeons Commission on Cancer, the National Accreditation Program for Breast Centers and the American College of Radiology

Care Designed With You in Mind

  • Comprehensive patient support, with five Norton Cancer Institute Resource Centers throughout Louisville and Southern Indiana, a patient navigator program, Norton Cancer Institute Behavioral Oncology Program, Norton Palliative Care Program, classes and events, art and music therapy, genetic counseling, nutrition services, financial counseling, pastoral care, and more
  • Medicare, Medicaid and most major insurances accepted, ensuring broad access to care
  • Specialty pharmacy services offer timely, accurate prescriptions with direct pharmacist-provider collaboration
  • 24/7 access to care tools via Norton MyChart — message providers, manage appointments, refill prescriptions and more
  • The Norton Healthcare Foundation, the philanthropic arm of Norton Healthcare’s not-for-profit adult-care services, continuously supporting the purchase of new equipment, programs, education and funding of research to ensure our patients stay up to date with medical advances and technology

Awards and Accreditations

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