Breast Cancer Clinical Trials | Norton Healthcare Louisville, Ky.

Breast Cancer Clinical Trials

Norton Cancer Institute is at the forefront of cancer treatment research. As principal investigators on numerous breast cancer clinical trials, our specialist physicians have access to innovative treatments.

Learn more about participating in a clinical trial at Norton Healthcare.

Active breast cancer clinical trials include:

Metastatic HER2+ Cancer

A randomized, double-blind, phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for metastatic HER2+ breast cancer (HER2CLIMB-05)

Triple Negative Breast Cancer (TNBC)

A phase III double-blind randomized study assessing the efficacy of capivasertib + paclitaxel versus placebo + paclitaxel as first-line treatment for patients with histologically confirmed, locally advanced or metastatic triple-negative breast cancer (TNBC)

HR Positive

A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator’s Choice Chemotherapy in HER2-low, Hormone Receptor Positive Breast Cancer Patients whose Disease has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06)

Advanced Malignancies

A Phase 2, Multi-arm, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of IPI-549 Administered in Combination with Front-line Treatment Regimens in Patients with Locally Advanced and/or Metastatic Triple-Negative Breast Cancer or Renal Cell […]

Triple Negative Breast Cancer (TNBC)

NRG-BR003: A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer

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Clinical trials

Clinical Trials

Learn more about clinical trials at Norton Healthcare
(502) 629-3500

Breast self-exams crucial for those under 40 who aren’t ready for screening mammograms

Laura Chamberlin first noticed a lump in her breast when she was a graduate student living in Seattle, Washington. She mentioned it to her primary care doctor, who told her not to worry. “She said, […]

Read Full Story

Derby Divas honoree Kimberley Marek’s cancer spotted on a 3D mammogram

In 2017, Kimberley Marek received a call after her mammogram, letting her know that something had come back abnormal. It wasn’t the first time this had happened. Since she has dense breast tissue, she had […]

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How to talk to your doctor about sex and cancer

Sexual health is important for any adult’s well-being, but patients with cancer face a new set of challenges when it comes to sexuality. Laila S. Agrawal, M.D., breast cancer oncologist with Norton Cancer Institute, is […]

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Swollen lymph nodes are a normal and harmless COVID-19 vaccine side effect

Swollen lymph nodes and the COVID-19 vaccine have been an issue for many, but the harmless side effect is causing alarm as some mistake the temporary underarm lump for a tumor. Swollen lymph nodes are […]

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Perhaps you put off cancer screening tests while staying safer at home. Delays of just a few months in detecting various forms of cancer can make treatment more difficult and reduce chances of survival. Here’s […]

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Breast self-exams crucial for those under 40 who aren’t ready for screening mammograms

Laura Chamberlin first noticed a lump in her breast when she was a graduate student living in Seattle, Washington. She mentioned it to her primary care doctor, who told her not to worry. “She said, […]

Read Full Story

Derby Divas honoree Kimberley Marek’s cancer spotted on a 3D mammogram

In 2017, Kimberley Marek received a call after her mammogram, letting her know that something had come back abnormal. It wasn’t the first time this had happened. Since she has dense breast tissue, she had […]

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