Breast Cancer Clinical Trials | Norton Healthcare Louisville, Ky.

Breast Cancer Clinical Trials

Norton Cancer Institute is at the forefront of breast cancer treatment research. As principal investigators on numerous trials, our specialist physicians have unparalleled experience with many innovative treatments once they are approved for broad use. Patients also may be eligible to take part in these experimental breast cancer treatments. Norton Cancer Institute researchers also contribute to groundbreaking studies and other publications in peer-reviewed journals.

Learn more about participating in a clinical trial at Norton Healthcare.

Current Breast Cancer Clinical Trials and Studies

HER2+ Early Stage Breast Cancer

A Phase 3 Open-label Trial of Neoadjuvant Trastuzumab Deruxtecan (T-DXd) Monotherapy or T-DXd followed by THP Compared to ddAC-THP in Participants with High-risk HER2-positive Early-stage Breast Cancer (DESTINY-Breast 11)
Study Type: Drug Study
Laila Agrawal  M.D.
Laila Agrawal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: AstraZeneca

HER2- Locally Advanced Metastatic Breast Cancer

A Phase III Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating The Efficacy And Safety Of GDC-9545 Combined With Palbociclib Compared With Letrozole Combined With Palbociclib In Patients With Estrogen Receptor-Positive, HER2-Negative Locally Advanced Or Metastatic Breast Cancer
Study Type: Drug Study
Jeffrey Hargis  M.D.
Jeffrey Hargis M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: F. Hoffmann-LaRoche Ltd.

HER2+ Unresectable or Metastatic

Phase III Study of Trastuzumab Deruxtecan (T-DXd) with or without Pertuzumab versus Taxane, Trastuzumab and Pertuzumab in HER2-positive, First-line Metastatic Breast Cancer (DESTINY-Breast09)
Study Type: Drug Study
Laila Agrawal  M.D.
Laila Agrawal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: AstraZeneca

Metastatic HER2+ Cancer

A randomized, double-blind, phase 3 study of tucatinib or placebo in combination with trastuzumab and pertuzumab as maintenance therapy for metastatic HER2+ breast cancer (HER2CLIMB-05)
Study Type: Drug Study
Laila Agrawal  M.D.
Laila Agrawal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Seagen Inc.

HR Positive

A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator’s Choice Chemotherapy in HER2-low, Hormone Receptor Positive Breast Cancer Patients whose Disease has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06)
Study Type: Drug Study
Laila Agrawal  M.D.
Laila Agrawal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: AstraZeneca

Breast Cancer

Collection of sentinel lymph node tissue, blood, urine and saliva from those undergoing surgery for melanoma or breast cancer for the purpose of research now and in the future.
Study Type: Specimen Study
Kelly McMasters M.D.
Kelly McMasters M.D.
Principal Investigator
University of Louisville Physicians - Surgical Oncology
Sponsor: UofL Investigator

Education

Effects of a Smartphone App on Compliance and Function in Patients with Breast Cancer
Study Type: Observational
Joseph Flynn, D.O.
Joseph Flynn, D.O., MPH, FACP
Principal Investigator
Norton Cancer Institute
Sponsor: NH Investigator

Recent Breast Cancer Research Published by Norton Cancer Institute Physicians

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Clinical trials

Clinical Trials

Learn more about clinical trials at Norton Healthcare
(502) 629-3500

Breast self-exams crucial for those under 40 who aren’t ready for screening mammograms

Laura Chamberlin first noticed a lump in her breast when she was a graduate student living in Seattle, Washington. She mentioned it to her primary care doctor, who told her not to worry. “She said, […]

Read Full Story

Derby Divas honoree Kimberley Marek’s cancer spotted on a 3D mammogram

In 2017, Kimberley Marek received a call after her mammogram, letting her know that something had come back abnormal. It wasn’t the first time this had happened. Since she has dense breast tissue, she had […]

Read Full Story

How to talk to your doctor about sex and cancer

Sexual health is important for any adult’s well-being, but patients with cancer face a new set of challenges when it comes to sexuality. Laila S. Agrawal, M.D., breast cancer oncologist with Norton Cancer Institute, is […]

Read Full Story

Swollen lymph nodes are a normal and harmless COVID-19 vaccine side effect

Swollen lymph nodes and the COVID-19 vaccine have been an issue for many, but the harmless side effect is causing alarm as some mistake the temporary underarm lump for a tumor. Swollen lymph nodes are […]

Read Full Story

If you’ve been putting off cancer screenings, here’s your guide to catching up

Perhaps you put off cancer screening tests while staying safer at home. Delays of just a few months in detecting various forms of cancer can make treatment more difficult and reduce chances of survival. Here’s […]

Read Full Story
Related Stories

Breast self-exams crucial for those under 40 who aren’t ready for screening mammograms

Laura Chamberlin first noticed a lump in her breast when she was a graduate student living in Seattle, Washington. She mentioned it to her primary care doctor, who told her not to worry. “She said, […]

Read Full Story

Derby Divas honoree Kimberley Marek’s cancer spotted on a 3D mammogram

In 2017, Kimberley Marek received a call after her mammogram, letting her know that something had come back abnormal. It wasn’t the first time this had happened. Since she has dense breast tissue, she had […]

Read Full Story

How to talk to your doctor about sex and cancer

Sexual health is important for any adult’s well-being, but patients with cancer face a new set of challenges when it comes to sexuality. Laila S. Agrawal, M.D., breast cancer oncologist with Norton Cancer Institute, is […]

Read Full Story

Swollen lymph nodes are a normal and harmless COVID-19 vaccine side effect

Swollen lymph nodes and the COVID-19 vaccine have been an issue for many, but the harmless side effect is causing alarm as some mistake the temporary underarm lump for a tumor. Swollen lymph nodes are […]

Read Full Story

If you’ve been putting off cancer screenings, here’s your guide to catching up

Perhaps you put off cancer screening tests while staying safer at home. Delays of just a few months in detecting various forms of cancer can make treatment more difficult and reduce chances of survival. Here’s […]

Read Full Story

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