Gastrointestinal Cancer Clinical Trials and Research | Norton Healthcare Louisville, Ky.

Gastrointestinal Cancer Clinical Trials and Research

Norton Cancer Institute is at the forefront of gastrointestinal cancer treatment research. As principal investigators on numerous trials, our specialist physicians have unparalleled experience with many innovative treatments once they are approved for broad use. Patients also may be eligible to take part in these experimental gastrointestinal cancer treatments. Norton Cancer Institute researchers also contribute to groundbreaking studies and other publications in peer-reviewed journals.

Learn more about participating in a clinical trial at Norton Healthcare.

Current Gastrointestinal Cancer Clinical Trials and Research

Esophageal Cancer

A Phase III, Randomized, Double-Blind, Placebo Controlled, Multi-Center International Study of Durvalumab Given Concurrently with Definitive Chemoradiation Therapy in Patients with Locally Advanced, Unresectable Esophageal Squamous Cell Carcinoma
Study Type: Drug Study
Michael Driscoll  M.D.
Michael Driscoll M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: AstraZeneca

Gastric Cancer

A Randomized, Double-blind, Placebo-controlled, Phase III Study of Neoadjuvant/Adjuvant Durvalumab and Standard Chemotherapy Followed by Adjuvant Durvalumab in Patients with Resectable Gastric and astroesophageal Cancer (GC/GEJC)
Study Type: Drug Study
Michael Driscoll  M.D.
Michael Driscoll M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: AstraZeneca

Gastric Cancer

A randomized, double-blind, placebo-controlled, active comparator Phase 2/3 study of tucatinib in combination with trastuzumab, ramucirumab, and paclitaxel in subjects with previously treated, locally-advanced unresectable or metastatic HER2+ gastric or gastroesophageal junction adenocarcinoma (GEC)
Study Type: Drug Study
Michael Driscoll  M.D.
Michael Driscoll M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Seattle Genetics, Inc

Hepatocellular Carcinoma (HCC)

A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation (KEYNOTE-937)
Study Type: Drug Study
Robert Martin  M.D., Ph.D.
Robert Martin M.D., Ph.D.
Principal Investigator
University of Louisville Physicians - Surgical Oncology
Sponsor: Merck Sharp & Dohme LLC

Metastatic Colorectal Cancer

A Phase 3 study of MK-4280A (coformulated favezelimab [MK-4280] plus pembrolizumab [MK-3475]) Versus Standard of Care in Previously Treated Metastatic PDL1 positive Colorectal Cancer
Study Type: Drug Study
Michael Driscoll  M.D.
Michael Driscoll M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Merck & Co., Inc

Metastatic Esophageal Carcinoma

A Phase 3, Randomized Study to Evaluate the Efficacy and Safety of Pembrolizumab (MK-3475) + Lenvatinib (E7080/MK-7902) + Chemotherapy Compared with Standard of Care as First-line Intervention in Participants with Metastatic Esophageal Carcinoma
Study Type: Drug Study
Michael Driscoll  M.D.
Michael Driscoll M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Merck Sharp & Dohme CORP

Pancreatic Cancer

A Randomized, Multicenter, Controlled, Unblinded Study to Assess the Safety and Efficacy of the NanoKnife® System for the Ablation of Unresectable Stage 3 Pancreatic Adenocarcinoma
Study Type: Device Study
Robert Martin  M.D., Ph.D.
Robert Martin M.D., Ph.D.
Principal Investigator
University of Louisville Physicians - Surgical Oncology
Sponsor: AngioDynamics, Inc.
Cancer – 4673

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Clinical trials

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Learn more about clinical trials at Norton Healthcare
(502) 629-3500

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