Breast Cancer Clinical Trials

Norton Cancer Institute is at the forefront of cancer treatment research. As principal investigators on numerous breast cancer clinical trials, our specialist physicians have access to innovative treatments.

Learn more about participating in a clinical trial at Norton Healthcare.

Active breast cancer clinical trials include:

Breast Cancer

A Phase III, Multicenter, Randomized, Open-label Trial to Evaluate Efficacy and Safety of Ribociclib with Endocrine Therapy as an Adjuvant Treatment in Patients with Hormone Receptor-Positive, HER2-Negative, Early Breast Cancer (New Adjuvant TriAl with Ribociclib […]

Breast Cancer

A phase I/II dose escalation and expansion study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of GSK525762 in combination with fulvestrant in subjects with hormone receptor-positive/HER2-negative (HR+/HER2-) advanced or metastatic breast cancer

Lung Cancer/ Breast Cancer

A Phase 1 Study to evaluate the safety, pharmacokinetics, and pharmacodynamics of escalating doses and treatment intensification of a vaccine-based immunotherapy Regimen-2 (VBIR-2) (PF-06936308) for advanced non-small cell lung cancer and metastatic triple-negative breast cancer

Cancer

A Phase 1b, Multicenter, Two-Part, Open-Label Study of DS-8201a, an Anti-Human Epidermal Growth Factor Receptor-2 (HER2)-Antibody Drug Conjugate (ADC), in Combination with Nivolumab, an anti-PD-1 antibody, for Subjects with HER2-expressing Advanced Breast and Urothelial Cancer

Metastatic Breast Cancer

A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (DS-8201A,), AN ANTI-HER2-ANTIBODY DRUG CONJUGATE, VERSUS ADO-TRASTUZUMAB EMTANSINE (T-DM1) FOR HER2-POSITIVE, UNRESECTABLE AND/OR METASTATIC BREAST CANCER SUBJECTS PREVIOUSLY TREATED WITH TRASTUZUMAB AND TAXANE

Metastatic Breast Cancer

A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (DS–8201A), AN ANTI-HER2-ANTIBODY DRUG CONJUGATE, VERSUS TREATMENT OF INVESTIGATOR’S CHOICE FOR HER2-POSITIVE, UNRESECTABLE AND/OR METASTATIC BREAST CANCER SUBJECTS PREVIOUSLY TREATED WITH T-DM1

Breast Cancer

Elacestrant Monotherapy Vs. Standard Of Care For The Treatment Of Patients With Er+/Her2- Advanced Breast Cancer Following Cdk4/6 Inhibitor Therapy: A Phase 3 Randomized, Open-Label, Active-Controlled, Multicenter Trial (EMERALD)

Breast Cancer

A Phase II, Open Label, Randomised, Multi-centre Study to Assess the Safety and Efficacy of Agents Targeting DNA Damage Repair in Combination with Olaparib versus Olaparib Monotherapy in the Treatment of Metastatic Triple Negative Breast […]

Breast Cancer

A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy with Atezolizumab or Placebo in Patients with Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo

Education

Effects of a Smartphone App on Compliance and Function in Patients with Breast Cancer

Solid Tumors

A Phase 2/3, Multicenter, Randomized, Double Blind, Study to Evaluate Duration of Severe Neutropenia with Plinabulin Versus Pegfilgrastim in Patients with Solid Tumors Receiving Docetaxel Myelosuppressive Chemotherapy

Breast Cancer

NRG-BR003: A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer

Breast Cancer

A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After […]

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Clinical trials

Clinical Trials

Learn more about clinical trials at Norton Healthcare
(502) 629-3501

Cokie Roberts’ 17-year breast cancer survival points to medical advances

When television journalist Cokie Roberts was diagnosed with breast cancer in 2002, she had reason to be optimistic. The 15-year survival rate for breast cancer patients was about 70%, meaning the odds were with her, […]

Read Full Story

Using vaccines to treat brain cancer: 4 things to know about this immunotherapy trial

Immunotherapy is a method of treating cancer, and new immune treatments are being studied across the country. Norton Cancer Institute is participating in a clinical trial conducted by AIVITA Biomedical Inc. to study whether a […]

Read Full Story

Why do I ride in Bike to Beat Cancer? Because I miss you, Rhonda

Ever have that work friend that turns into a real friend? Rhonda Hoffman was that real friend. We met not long after I moved here from Cincinnati for a career change. After several years, we […]

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Thomas M. Woodcock, M.D., to retire; pioneered cancer care in Louisville and Southern Indiana

Thomas M. Woodcock, M.D., came to Louisville in 1981 and was one of four founders of what is now Norton Cancer Institute. After almost 40 years as a medical oncologist, Dr. Woodcock plans to retire […]

Read Full Story

New dad gets ependymoma brain tumor diagnosis one day after son’s birth

March 2016 was a life-changing time for the Davis family. On March 23, Matt Davis and his wife, Hailey, celebrated the birth of their son, Finley. The next day, Matt learned he had a rare […]

Read Full Story
Related Stories

Cokie Roberts’ 17-year breast cancer survival points to medical advances

When television journalist Cokie Roberts was diagnosed with breast cancer in 2002, she had reason to be optimistic. The 15-year survival rate for breast cancer patients was about 70%, meaning the odds were with her, […]

Read Full Story

Using vaccines to treat brain cancer: 4 things to know about this immunotherapy trial

Immunotherapy is a method of treating cancer, and new immune treatments are being studied across the country. Norton Cancer Institute is participating in a clinical trial conducted by AIVITA Biomedical Inc. to study whether a […]

Read Full Story

Why do I ride in Bike to Beat Cancer? Because I miss you, Rhonda

Ever have that work friend that turns into a real friend? Rhonda Hoffman was that real friend. We met not long after I moved here from Cincinnati for a career change. After several years, we […]

Read Full Story

Thomas M. Woodcock, M.D., to retire; pioneered cancer care in Louisville and Southern Indiana

Thomas M. Woodcock, M.D., came to Louisville in 1981 and was one of four founders of what is now Norton Cancer Institute. After almost 40 years as a medical oncologist, Dr. Woodcock plans to retire […]

Read Full Story

New dad gets ependymoma brain tumor diagnosis one day after son’s birth

March 2016 was a life-changing time for the Davis family. On March 23, Matt Davis and his wife, Hailey, celebrated the birth of their son, Finley. The next day, Matt learned he had a rare […]

Read Full Story

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