Head and Neck Cancer Clinical Trials | Norton Healthcare Louisville, Ky.

Head and Neck Cancer Clinical Trials

Norton Cancer Institute is at the forefront of cancer treatment research. As principal investigators on numerous trials, our specialist physicians have access to innovative treatments.

Learn more about participating in a clinical trial at Norton Healthcare.

Active head and neck cancer trials at Norton Cancer Institute include:

Head and Neck Cancer

Phase II, Open-Label, Multi-Center Study of PDS0101 (ImmunoMAPK-RDOTAP/HPV-16 E6 & E7 peptides) and Pembrolizumab (KEYTRUDA) Combination Immunotherapy as a First Line Treatment in Subjects with Recurrent and/or Metastatic Head and Neck Cancer (HNSCC) and High-risk […]

Head and Neck Cancer

An open label Phase II randomized trial of BNT113 in combination with pembrolizumab versus pembrolizumab monotherapy as a first line therapy in patients with unresectable recurrent, or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) […]

Head and Neck Cancer

NRG-HN004: Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin

Head and Neck Cancer

ROMAN: Reduction in Oral Mucositis with Avasopasem Manganese (GC4419) – Phase 3 Trial in Patients Receiving Chemoradiotherapy for Locally-Advanced, Non-Metastatic Head and Neck Cancer

Oropharyngeal Cancer

NRG-HN005: A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, p16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Squamous Cell Carcinoma

Phase III Study of Buparlisib (AN2025) Plus Paclitaxel Compared to Paclitaxel Alone in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma

The AIM-HN and SEQ-HN Study: A 2 Cohort, Non-comparative, Pivotal Study Evaluating the Efficacy of Tipifarnib in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) with HRAS Mutations (AIM-HN) and the Impact of HRAS […]

Squamous Cell Carcinoma

AstraZeneca INTERLINK-1 Monalizumab HNSCC Study

Squamous Cell Carcinoma

A randomized, double-blind placebo-controlled, Phase 3 study of Debio 1143 in combination with platinum-based chemotherapy and standard fractionation intensity-modulated radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck, suitable for […]

Squamous Cell Carcinoma

A Phase 1b, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-368 plus Tilsotolimod and Other Therapy Combinations in Subjects with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

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Clinical trials

Clinical Trials

Learn more about clinical trials at Norton Healthcare
(502) 629-3500

Breast self-exams crucial for those under 40 who aren’t ready for screening mammograms

Laura Chamberlin first noticed a lump in her breast when she was a graduate student living in Seattle, Washington. She mentioned it to her primary care doctor, who told her not to worry. “She said, […]

Read Full Story

After years of watching, Debbie Cobb decided to ride

Each year, Debbie Cobb would see Bike to Beat Cancer setting up from her office on the Norton Brownsboro Hospital campus. She would see the big tents going up and hear everyone on campus getting […]

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Derby Divas honoree Kimberley Marek’s cancer spotted on a 3D mammogram

In 2017, Kimberley Marek received a call after her mammogram, letting her know that something had come back abnormal. It wasn’t the first time this had happened. Since she has dense breast tissue, she had […]

Read Full Story

Can you reduce prostate cancer risks with healthy choices? Study shows promising results.

Can you stave off lethal prostate cancer by changing your diet and lifestyle? Promising research suggests yes: Those changes can go a long way in reducing the risk of developing the worst type of this […]

Read Full Story

New York City resident to spend 9/11 at Bike to Beat Cancer

Brian Haskel is preparing for his eighth Bike to Beat Cancer ride. Each year, he rides in honor of loved ones touched by cancer. “I lost many relatives to cancer who were taken too young,” […]

Read Full Story
Related Stories

Breast self-exams crucial for those under 40 who aren’t ready for screening mammograms

Laura Chamberlin first noticed a lump in her breast when she was a graduate student living in Seattle, Washington. She mentioned it to her primary care doctor, who told her not to worry. “She said, […]

Read Full Story

After years of watching, Debbie Cobb decided to ride

Each year, Debbie Cobb would see Bike to Beat Cancer setting up from her office on the Norton Brownsboro Hospital campus. She would see the big tents going up and hear everyone on campus getting […]

Read Full Story

Derby Divas honoree Kimberley Marek’s cancer spotted on a 3D mammogram

In 2017, Kimberley Marek received a call after her mammogram, letting her know that something had come back abnormal. It wasn’t the first time this had happened. Since she has dense breast tissue, she had […]

Read Full Story

Can you reduce prostate cancer risks with healthy choices? Study shows promising results.

Can you stave off lethal prostate cancer by changing your diet and lifestyle? Promising research suggests yes: Those changes can go a long way in reducing the risk of developing the worst type of this […]

Read Full Story

New York City resident to spend 9/11 at Bike to Beat Cancer

Brian Haskel is preparing for his eighth Bike to Beat Cancer ride. Each year, he rides in honor of loved ones touched by cancer. “I lost many relatives to cancer who were taken too young,” […]

Read Full Story

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