Head and Neck Cancer Clinical Trials | Norton Healthcare Louisville, Ky.

Head and Neck Cancer Clinical Trials

Norton Cancer Institute is at the forefront of cancer treatment research. As principal investigators on numerous trials, our specialist physicians have access to innovative treatments.

Learn more about participating in a clinical trial at Norton Healthcare.

Active head and neck cancer trials at Norton Cancer Institute include:

Current Head and Neck Tumor Clinical Trials and Studies

Head and Neck Cancer

Phase II, Open-Label, Multi-Center Study of PDS0101 (ImmunoMAPK-RDOTAP/HPV-16 E6 & E7 peptides) and Pembrolizumab (KEYTRUDA) Combination Immunotherapy as a First Line Treatment in Subjects with Recurrent and/or Metastatic Head and Neck Cancer (HNSCC) and High-risk Human Papillomavirus-16 (HPV16) Infection
Study Type: Drug Study
Jaspreet Grewal M.D.
Jaspreet GrewalM.D.
Principal Investigator
Norton Cancer Institute
Sponsor: PDS Biotechnology Corporation

Head and Neck Cancer

An open label Phase II randomized trial of BNT113 in combination with pembrolizumab versus pembrolizumab monotherapy as a first line therapy in patients with unresectable recurrent, or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) which is positive for human papilloma virus 16 (HPV16+) and expresses PD-L1
Study Type: Drug Study
Jaspreet Grewal  M.D.
Jaspreet Grewal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: BioNTech RNA Pharmaceuticals GmbH

Oropharyngeal Cancer

NRG-HN005: A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, p16-Positive, Non-Smoking Associated Oropharyngeal Cancer
Study Type: Drug Study
Aaron Spalding  M.D.
Aaron Spalding M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: NRG Oncology

Squamous Cell Carcinoma

Phase III Study of Buparlisib (AN2025) Plus Paclitaxel Compared to Paclitaxel Alone in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Study Type: Drug Study
Jaspreet Grewal  M.D.
Jaspreet Grewal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Adlai Nortye USA Inc

Squamous Cell Carcinoma

The AIM-HN and SEQ-HN Study: A 2 Cohort, Non-comparative, Pivotal Study Evaluating the Efficacy of Tipifarnib in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) with HRAS Mutations (AIM-HN) and the Impact of HRAS Mutations on Response to First Line Systemic Therapies for HNSCC (SEQ-HN)
Study Type: Drug Study
Jaspreet Grewal  M.D.
Jaspreet Grewal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Kura Oncology, Inc.

Squamous Cell Carcinoma

A randomized, double-blind placebo-controlled, Phase 3 study of Debio 1143 in combination with platinum-based chemotherapy and standard fractionation intensity-modulated radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck, suitable for definitive chemoradiotherapy (TrilynX)
Study Type: Drug Study
Aaron Spalding  M.D.
Aaron Spalding M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Debiopharm International S.A

Squamous Cell Carcinoma

A Phase 2 Study of the Combination of Pepinemab and Pembrolizumab in Patients with Advanced, Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Study Type: Drug Study
Jaspreet Grewal  M.D.
Jaspreet Grewal M.D.
Principal Investigator
Norton Cancer Institute
Sponsor: Vaccinex Inc.
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Clinical trials

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Learn more about clinical trials at Norton Healthcare
(502) 629-3500

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